Using a novel method to delineate enhancer-gene interactions, Corradin et al. show that multiple enhancer variants within a given locus typically target the same gene. Using available data from HapMap and B lymphoblasts as a model system, they provide evidence at numerous loci that multiple enhancer variants cooperatively contribute to altered expression of their gene targets.

Corradin, O., Saiakhova, A., Akhtar-Zaidi, B., Myeroff, L., Willis, J., Cowper-Sal, R., ... & Scacheri, P. C. (2014). Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits. Genome research, 24(1), 1-13.