He et al. develop and integrate multiple genomic features into a statistical predictor for enhancer–promoter interactions. Systematic analyses of the predicted interactions across 12 cell types reveals several global features of enhancer–promoter communication. The approach presents a systematic and effective strategy to decipher the mechanisms underlying enhancer and promoter communication.

He, B., Chen, C., Teng, L., & Tan, K. (2014). Global view of enhancer–promoter interactome in human cells. Proceedings of the National Academy of Sciences, 111(21), E2191-E2199.


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