EpiTensor

Zhu et al. present EpiTensor, an algorithm to identify 3D spatial associations within topologically associating domains (TADs) from 1D maps of histone modifications, chromatin accessibility and RNA-seq. We demonstrate that active promoter–promoter, promoter–enhancer and enhancer–enhancer associations identified by EpiTensor are highly concordant with those detected by Hi-C, ChIA-PET and eQTL analyses at 200 bp resolution.

Zhu, Y., Chen, Z., Zhang, K., Wang, M., Medovoy, D., Whitaker, J. W., ... & Wang, W. (2016). Constructing 3D interaction maps from 1D epigenomes. Nature communications, 7(1), 1-11.

Examples:

EpiTensor test case:

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Examples:

EpiTensor test case:
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